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CLINICAL AND IMMUNOLOGICAL ASPECTS OF THE COURSE

OF MYOCARDIAL INFARCTION ASSOCIATED

WITH DIABETES MELLITUS DURING HOSPITAL TREATMENT

E.A.Skorodumova Institute for Emergency Medical Care n.a. I. I. Dzhanelidze, Department of Emergency Cardiology and Rheumatology, Senior Research Assistant, Candidate of Medical Science; V .


A.Kostenko Institute for Emergency Medical Care n.a. I. I. Dzhanelidze, Head of Department of Emergency Cardiology and Rheumatology, Candidate of Medical Science; A.V.Siverina Institute for Emergency Medical Care n.a. I. I. Dzhanelidze, Department of Emergency Cardiology and Rheumatology, Cardiologist; A.N.Fedorov Institute for Emergency Medical Care n.a. I. I. Dzhanelidze, Department of Emergency Cardiology and Rheumatology, Cardiologist .

27.06.2015 . 28.08.15 .

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SkorodumovaEA,KostenkoVA,SiverinaAV,FedorovAN. Clinical and immunological aspects of the course of myocardial infarction associated with diabetes mellitus during hospital treatment. Saratov Journal of Medical Scientific Research 2015; 11 (3): 287290 .

The aim of the study was to provide the data on the course of myocardial infarction (MI) associated with diabetes mellitus (DM) in hospital. Material and methods. 102 patients with MI were included in two cohorts, first with DM, second without DM. Groups were compatible by gender, age and standard therapy. Results. Angiocoronarography data have revealed that patients of group 1 were characterized by multiple vessels lesion due to rescue angioplasty with stenting performed 5 times. Patients with DM demonstrated in-hospital higher rate of both acute (by Killip) and chronic (by NYHA) heart failure of advanced degrees as well as recurrent MI, early postinfarction angina pectoris, heart rhythm disorders and hematomas due to injections. Conclusion. The previously mentioned results lead to higher mortality in this group. Significant elevation of CRP, interleukin-6 and epidermal growth factor levels proved more activated systemic inflammatory response in patients with MI and DM playing key role in pathogenesis of complications of the disease .

Key words: myocardial infarction, diabetes mellitus, in-hospital phase, systemic inflammation .

   

- . 2015. . 11, 3 .






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